Avalanche Biotechnologies Presents Three Posters at American Society of Gene & Cell Therapy (ASGCT) Annual Meeting
AVA-101 (rAAV.sFlt-1) is being developed as a single treatment to provide a safe and effective therapy for wet age-related macular degeneration (wet AMD) that is durable and reduces the need for frequent anti-VEGF injections. The Phase 2a clinical trial is currently ongoing to evaluate the safety of a single injection of rAAV.sFlt-1 in subjects with wet AMD. Twelve-month data from the study and 36-month follow-up from the Phase 1 trial are expected mid-year.
The poster, entitled, "Baseline Data for Patients Participating in the Phase 2a rAAV.sFlt-1 Gene Therapy Trial for Exudative Age-Related Macular Degeneration" will be presented by
- Enrolled subjects are representative of the wet AMD population under current treatment with anti-VEGF therapy with variable visual acuity and prior treatment. Subjects were randomized 2:1 to receive a single sub-retinal injection of 1E11 vg rAAV.sFlt-1 or 0.5 mg ranibizumab alone.
- The mean age of the subjects is 79 ± 7; median visual acuity was 63 ETDRS letters.
- The median number of previous anti-VEGF injections for non-naïve patients is 10, with three of the 32 subjects being treatment naïve.
In addition, Avalanche is presenting the following posters at the annual meeting:
|Poster: Evaluating AAV Hybrid Variants for Improved Tropism after Intravitreal Gene Delivery to the Retina|
|Presenter: Annahita Keravala, PhD, Avalanche Biotechnologies|
|Date/Time: Thursday, May 14, 5:30 – 7:00 p.m. CT|
|Poster: pMNTC is a Cone-Specific Regulatory Cassette Designed to Treat Cone-Associated Disorders|
|Presenter: Kathryn Woodburn, PhD, Avalanche Biotechnologies|
|Presented on Wednesday, May 13, 5:15 – 6:45 p.m. CT|
About Avalanche Biotechnologies, Inc.
Avalanche is a biopharmaceutical company committed to improving or preserving the sight of people suffering from blinding eye diseases with an unmet medical need. Avalanche's proprietary Ocular BioFactory™ is a platform for discovering and developing novel medicines with the potential to offer life-changing therapeutic benefit. Avalanche's lead product candidate, AVA-101, is in mid-stage clinical development for patients with wet age-related macular degeneration. For more information, please visit www.avalanchebiotech.com.
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1 Data, including the visual acuity at baseline, is subject to final CRO audit and verification. Data is further subject to protocol-specified full cleaning and query prior to database lock and analysis.
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